Journal article
The preventable burden of endometrial and ovarian cancers in Australia: A pooled cohort study
MA Laaksonen, ME Arriaga, K Canfell, RJ MacInnis, JE Byles, E Banks, JE Shaw, P Mitchell, GG Giles, DJ Magliano, TK Gill, E Klaes, LS Velentzis, V Hirani, RG Cumming, CM Vajdic
Gynecologic Oncology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019
Abstract
Objective: Evidence on the endometrial and ovarian cancer burden preventable through modifications to current causal behavioural and hormonal exposures is limited. Whether the burden differs by population subgroup is unknown. Methods: We linked pooled data from six Australian cohort studies to national cancer and death registries, and quantified exposure-cancer associations using adjusted proportional hazards models. We estimated exposure prevalence from representative health surveys. We then calculated Population Attributable Fractions (PAFs) with 95% confidence intervals (CIs), accounting for competing risk of death, and compared PAFs for population subgroups. Results: During a median 4.9 ..
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Grants
Awarded by Eli Lilly and Company
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (ID1060991). The National Health and Medical Research Council of Australia also supported Dr. Laaksonen (ID1053642), Prof. Canfell (ID1082989), Prof. Banks (ID1136128), Prof. Shaw (ID1079438) and Prof. Magliano (ID1118161). Dr. Laaksonen was additionally supported by the Cancer Institute New South Wales (ID13/ECF/1-07). Dr. Arriaga was supported by an Australian Postgraduate Award and a Translational Cancer Research Network (TCRN) PhD Scholarship Top-up Award.